Genetic Diagnosis in Cyprus IVF Treatment

The main goal in IVF treatment is not only to achieve pregnancy but to ensure you hold a healthy baby in your arms. Op. Dr. Emine Efendi uses Cyprus’s advanced technological laboratory facilities to genetically examine embryos before transfer and select the healthiest one. Genetic Diagnosis (PGD/PGS) methods prevent recurrent failures while opening the doors to a healthy future.

What is Genetic Diagnosis (PGT/PGS)?

Genetic diagnosis is the examination of embryos developed in a laboratory environment via IVF for chromosomal abnormalities or single-gene diseases before they are transferred to the mother’s womb. Thanks to this process, numerical chromosomal disorders (such as Trisomy 21 – Down Syndrome) or hereditary diseases from the family can be detected before pregnancy occurs.

How is Genetic Diagnosis Performed in IVF in Cyprus?

The process is carried out with a very delicate microsurgical procedure that does not harm the embryo:

1. Biopsy: When the embryo reaches the 5th day (Blastocyst stage), a few cells are taken from its outer layer (cells that will form the placenta in the future).

2. Genetic Analysis: The collected cells are examined in advanced genetic laboratories.

3. Freezing: Embryos are frozen using the vitrification method until the analysis results are available.

4. Transfer: Only embryos confirmed to be “genetically normal” (Euploid) are thawed and transferred.

For Whom is Genetic Diagnosis Recommended?

Although genetic screening is an option for every couple, it is medically recommended especially in the following cases:

• Advanced Maternal Age: Because the risk of chromosomal abnormalities increases in expectant mothers aged 35 and older.

• Recurrent IVF Failure: In cases where pregnancy does not occur despite high-quality embryo transfer.

• Recurrent Miscarriages: To prevent miscarriages caused by genetic reasons.

• Hereditary Disease Carriage: If there is a known genetic disease in the family (Thalassemia, SMA, Cystic Fibrosis, etc.).

• Severe Male Factor: In cases with serious abnormalities in sperm parameters.

Which Genetic Tests are Applied in Cyprus?

The most modern genetic analysis methods are used in our clinic in Cyprus:

• PGT-A (PGS): Numerical examination of chromosomes (comprehensive chromosome screening).

• PGT-M (PGD): Detection of a specific known single-gene disease in the family.

• PGT-SR: Examination of structural chromosomal rearrangements (translocation, etc.).

• NGS (Next Generation Sequencing): The most comprehensive and newest generation sequencing technology; the method with the lowest margin of error.

[Image showing the difference between normal and aneuploid chromosomes in embryo screening]

Differences Between PGT and PGS

Although they are often used interchangeably, there are technical differences:

• PGS (Genetic Screening): A general chromosome screening performed to understand if embryos are healthy even if there is no known disease in the family.

• PGD (Genetic Diagnosis): A targeted test performed to understand if a specific disease known to exist in the family (e.g., Thalassemia) is present in the embryo.

Genetic Diagnosis Process in Cyprus

The genetic diagnosis process with Op. Dr. Emine Efendi is carried out with transparent communication. Embryo development is monitored after egg collection (OPU). 5. After the biopsy is performed on the 5th day, couples are informed according to the report from the genetic laboratory. Cyprus’s legal legislation allows these tests to be implemented fully ethically and safely.

Genetic Diagnosis Success Rates Cyprus

Pregnancy rates increase significantly after the transfer of a genetically diagnosed embryo. Because it is known in advance that the transferred embryo is healthy. With this method:

• Pregnancy chance increases.

• Miscarriage risk is minimized.

• The “take-home baby” rate is maximized.

• The treatment process (time to achieve pregnancy) is shortened.

Embryo Transfer After Genetic Diagnosis

The embryo with a “Normal” genetic report is transferred when the expectant mother’s uterus is most suitable. Embryos that have undergone genetic screening are usually placed via a frozen embryo transfer (FET) cycle, which ensures the uterus is more rested and receptive.

Advantages of Genetic Tests in Cyprus

• Healthy Baby Guarantee: A pregnancy process free from genetic diseases.

• Psychological Comfort: Reduced concerns about the baby’s health.

• Cost and Time Savings: Preventing the waste of time and cost associated with incorrect embryo transfers.

• Advanced Technology: Easy access to world-standard NGS technology in Cyprus.